![]() There was a significant (P < 0.02, exact Fisher test) intergroup difference (95% vs 62%) with respect to the activating effect of CHLP. In group B, SD and CHLP activated sleep EEG in 12 (57%) and 13 (62%) patients respectively. This difference reached the limit of statistical significance (P = 0.05, McNemar test). In group A, SD and CHLP activated sleep EEG in 12 (60%) and 19 (95%) patients, respectively. All EEG recordings were scored by one observer according to a fixed protocol. A control group consisted of 18 healthy, volunteers (group C). The remaining 21 patients (group B) were treated with antiepileptic drugs (AED). Twenty out of 41 patients (group A) were not yet treated because of either recent onset of epilepsy or misdiagnosis. ![]() Patients were selected on the basis of both seizure onset in adulthood and normal interictal awake EEG recordings. We prospectively compared the activating effect of chlorpromazine (CHLP, 50 mg, i.m.) versus sleep deprivation (SD) in 41 patients with a clinical diagnosis of partial epilepsy.
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